Figure 6

The effect of miR-193a-3p and miR-193a-5p on both tumor growth and PA chemoresistance of 5637- and H-bc-derived xenografts in nude mice. (a) The experimental scheme, 5637 cells or H-bc cells were subcutaneously injected at four points at the back of each nude mice, respectively. From day 4, PBS, the indicted agomiR/antagomiR or the scramble sequence control (Mock) was intratumorly injected into 5637/H-bc, respectively, once every 2 days for five times as indicated. From day 6, each of the three mice for 5637 or H-bc received the intraperitoneal injection of PBS or Pa once every 2 days for five times, respectively. (b) The image of the representative mice with tumors on the day 25. (c) The mean±S.D. of tumor weight of the tumor from same treatment was calculated and plotted, *P<0.05 and summarized in the table. (d and e) The 5637 or H-bc tumor tissues from each group were fixed on one same slide and immunostained with the indicated antibodies. Levels of Ki67, SRSF2 and TP73 proteins in each indicated tumor tissues were scored and summarized