Figure 4 | Cell Death & Disease

Figure 4

From: MEIS2 is essential for neuroblastoma cell survival and proliferation by transcriptional control of M-phase progression

Figure 4

MEIS2 depletion leads to global downregulation of late cell-cycle genes. (a) GO analysis of the genes downregulated by shMEIS2-43 in BE(2)-C cells (FDR<1%). The number of genes for each biological process category is indicated. (b–e) GSEA showing significant enrichment of the gene sets involved in DNA replication (b), M phase (c), G2-M checkpoints (d), and mitotic sister chromatid segregation (e), with a majority of these genes being downregulated in response to MEIS2 depletion

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