Figure 5
From: Glucose metabolism is inhibited by caspases upon the induction of apoptosis
Caspase decreases the production of cellular ATP, PEP and P-serine during apoptosis. HeLa cells were treated with 1 μM actinomycin D for 6 h, at which time a metabolomic analysis of key glycolysis-related metabolites was performed. (a) ATP and ADP, (b) glycolytic products, (c) product of the TCA cycle, (d) products of the pentose phosphate pathway, (e) P-ser and (f) nucleotides intermediates measurements. Statistical analyses were performed for each metabolite between not treated (CTR) and actinomycin D conditions (Act D). *P<0.05; when not indicated, the differences did not reach significance; α-KG, α-ketoglutarate; 6-PG, 6-phosphogluconic acid; R5P, ribose-5-phosphate; Rib5P, ribulose 5-phosphat; Sed7P, sedoheptulose-7-phosphate; Xylu5P, xylulose 5-phosphate
