Figure 4
From: JNK–NQO1 axis drives TAp73-mediated tumor suppression upon oxidative and proteasomal stress
ROS-activated JNK kinase phosphorylates TAp73 and contributes to cell killing by WA. (a) WA triggers the phosphorylation of JNK kinase and TAp73. (b and c) WA promotes phosphorylation of threonine and serine residues in TAp73. (d) The SP600125 JNK inhibitor prevents phosphorylation of TAp73 on threonine residues by WA. (e) 20 μM SP600125 significantly protects from WA-mediated growth inhibition. (f) SB203580, a p38 kinase inhibitor, does not protect H1299 and HCT116TP53−/− cells from WA-mediated growth inhibition
