Figure 3
From: Impact of conditional deletion of the pro-apoptotic BCL-2 family member BIM in mice
Induced deletion of Bimfl in mature animals leads to increased WBC numbers and abnormalities in the composition of thymocyte subpopulations. Blood from (a) Bimfl/fl/Vav-CreER-tg and control mice as well as from (b) Bimfl/fl/Rosa-CreER-tg and control mice was analyzed with an ADVIA blood analyzer after the animals had been treated with 4-OHT, as described in Figure 2. (c) Thymocytes of mice of the indicated genotypes from a and b were stained with anti-CD4-PE and anti-CD8-FITC and analyzed by flow cytometry. N=4–8 mice for each genotype. Data represent mean±S.E.M. *P<0.05, **P<0.01, ***P<0.001 (paired t-test)
