Figure 1

Characterization of CPT-loaded NPs. (a) Schematic of drug-loaded PEG-PLGA NPs. (b) SEM images of CPT-loaded PLGA and PEG-PLGA NPs, scale bar represents 100 nm. (c) Flow cytometric cell cycle analysis (RNase A/PI staining) of murine colorectal MC38 cancer cells following treatment with different CPT formulations (0.12 μM) for 24 h. (d) Cell viability of MC38 cells following treatment with different CPT formulations for 48 h was assessed by MTT assay, mean±S.E.M., n=3