Table 1 Drug loading (per mg of polymer), size and polydispersity index (PDI) of CPT- and/or ABT-737-loaded NPs, mean±S.D., n≥4

From: Nanoencapsulation of ABT-737 and camptothecin enhances their clinical potential through synergistic antitumor effects and reduction of systemic toxicity

Formulation

ABT-737 ( μ g/mg)

CPT ( μ g/mg)

Polymer

Size (nm) a

PDI a

1

—

—

PLGA

181±13

0.06±0.04

2

—

—

PEG-PLGA

160±14

0.07±0.04

3

—

26±5

PLGA

203±19

0.21±0.11

4

—

26±1

PEG-PLGA

187±5

0.14±0.04

5

33±6

—

PEG-PLGA

166±11

0.10±0.07

6

—

2.9±0.3

PEG-PLGA

173±7

0.09±0.09

7

34±6

1.8±0.7

PEG-PLGA

169±12

0.06±0.02

8

263±26

—

PEG-PLGA

212±7

0.11±0.10

9

—

12±2

PEG-PLGA

197±4

0.17±0.05

10

273±17

12±2

PEG-PLGA

212±10

0.12±0.05

  1. aMeasured in PBS
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