Figure 1 | Cell Death & Disease

Figure 1

From: Analysis of BH3-only proteins upregulated in response to oxygen/glucose deprivation in cortical neurons identifies Bmf but not Noxa as potential mediator of neuronal injury

Figure 1

Induction of BH3-Only proteins in response to OGD in cortical neurons. Real-time qPCR analysis of mRNA expression of BH3-only proteins in cortical neurons subjected to 45 min OGD and allowed to recover under normoxic conditions for the times indicated. Controls were maintained under normoxic conditions. (a) mRNA levels for noxa were found to be upregulated from 4 h, and levels were maintained significantly up to 24 h. (b) bmf mRNA is not significantly induced by OGD. (c and d) Other markers investigated, bim and puma, respectively, showed no significant change when compared with control. Data were normalized to β-actin levels and expressed as relative to controls; presented as mean±S.E.M.; n=3 separate experiments carried out in triplicate. *P<0.05 compared with sham-treated control (ANOVA, post hoc Tukey’s test)

Back to article page