Figure 4

noxa-Deficiency confers no protection against ischemic injury. Infarct volume was assessed 24 h after focal cerebral ischemia by cresyl violet/Nissl staining. Infarct volume was calculated for direct infarct volume and corrected for edema of infarcted tissue for (a) total indirect infarct volume and (b) indirect infarct volume of each section. Mice deficient in noxa failed to influence infarct size compared with WT (Mann–Whitney U test). Results were quantified and presented as a percentage of infarct volume compared with WT treated. (c and d) Neurological deficit scores after induction of tMCAO in WT and noxa-deficient mice at 0 and 24 h following 60 min ischemia with reperfusion. No differences in neurological scoring outcome were found between noxa-deficient compared with WT matched controls after 24 h reperfusion. Circles and bar represent deficit score and median score, respectively. Data are representative of n≥4–5 for each group WT and noxa-deficient mice