Figure 6
From: A role for intracellular zinc in glioma alteration of neuronal chloride equilibrium
Model of glioma-induced EGABA shift. Glutamate released from glioma cells (1) causes GluR-dependent (2) neuronal [Zn2+]i increase (3), Src/TrkB-mediated KCC2 inactivation (4) leading to [Cl−]i increase (5) and EGABA shift (6)
