Figure 1
From: Nuclear iASPP may facilitate prostate cancer progression
Phenotypic analysis of iASPPΔ8/Δ8 mouse prostates. (a) The prostate glands of iASPPΔ8/Δ8 mice were macroscopically similar to those of wild-type mice. (b) iASPPΔ8/Δ8 mouse prostate lobes developed with an intact epithelial lining and a lumen. (c) iASPPΔ8/Δ8 mouse (n=3) prostate lobes demonstrated a small reduction in the number of Ki67-positive actively proliferating epithelial cells compared with iASPP+/+ (n=3) controls. (d) iASPPΔ8/Δ8 (n=4) mice demonstrated a small reduction in the number of BrdU-labelled cells in each lobe of the prostate following BrdU injection compared with iASPP+/+ (n=3) controls. (e) iASPPΔ8/Δ8 mice (n=5) demonstrated a small reduction in the number of TUNEL-positive apoptotic epithelial cells in each lobe of the prostate compared with iASPP+/+ (n=5) controls. (f) iASPPΔ8/Δ8 mice (n=5) had significantly fewer p63-positive basal epithelial cells compared with iASPP+/+ mice (n=5). The expression level of TP63 in prostate protein extracts from iASPPΔ8/Δ8 mice was diminished compared with iASPP+/+ controls
