Figure 5

Increased iASPP expression in prostate cancer samples is associated with an adverse clinical prognosis. (a) Increased nuclear iASPP expression in intermediate grade (Gleason sum score 7) prostate cancers was associated with increased prostate cancer-specific death after 10 years of follow-up following radical surgery. Increased cytoplasmic iASPP in high grade (Gleason sum score ≥8) prostate cancer samples was associated with an increased risk of both prostate cancer bone metastasis development and prostate cancer-specific death after 10 years of follow-up following radical surgery. (b) Increased nuclear iASPP expression was associated with a poor clinical outcome in men treated surgically for non organ-confined (≥pT3a) prostate cancer. High nuclear iASPP in this group of patients was associated with an increased risk of prostate cancer-specific death following radical surgery