Figure 2 | Cell Death & Disease

Figure 2

From: Identification and characterization of the novel Col10a1 regulatory mechanism during chondrocyte hypertrophic differentiation

Figure 2

Bioinformatics prediction of TFBS within 150-bp Col10a1 cis-enhancer. (a) TFSEARCH with a cutoff score of 85 identified 15 putative TFBSs including CdxA (six times), C-Rel, S8 (twice) and Nkx-2 etc (see also Supplementary Data S1). (b) Promo 3.0 program (with 85 similarity) identified approximately 200 putative TFs, including many AP1s (c-fos, c-Jun, ATF and JDP families), Hif and αMEF-2 (see also Supplementary Data S2). (c) TRAP identified approximately 50 TFs that showed a P-value <0.05, including Hoxa3, CACD and αMEF-2 (see also Supplementary Data S3). (d) The MATCH program (with a matrix score of 90) identified six putative TFs including Tst-1, RSRFC4, FOXJ2, OG-2, TBX5 and CACD (see also Supplementary Data S4)

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