Figure 1 | Cell Death & Disease

Figure 1

From: A Smoothened receptor agonist is neuroprotective and promotes regeneration after ischemic brain injury

Figure 1

PUR is neuroprotective in a mouse model of ischemic stroke. (a) Experimental design. PUR or VEH was administered i.v. at 6 h and 4 d after MCAO. Shh antagonist CyP (10 mg/kg) was injected i.v. 40 min before PUR administration. (b) Infarct area detected by TTC staining in animals treated with VEH, PUR (15 mg/kg) or CyP and PUR (15 mg/kg). (c) Quantitative analysis of TTC (n=8–10). Data are the means±S.E.M.; *P<0.05. Time to (d) sense and (e) remove adhesive from the contralateral front pawn in the adhesive-removal test (n=8–9). (f) Time on rotarod shown as the percentage to the time recorded on the last day of training (n=8–10; *P<0.05 compared with SHAM; #VEH versus PUR). mRNA levels of (g) Shh and (h) Gli1 in the cortex after MCAO (n=3–6; *P<0.05; **P<0.01, ***P<0.001)

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