Figure 8
From: PGC-1α buffers ROS-mediated removal of mitochondria during myogenesis

Schematic model of PGC-1α function in regulation of mitochondrial content during myogenesis. During myogenesis, PGC-1α maintains mitochondrial homeostasis ensuring mitochondrial biogenesis, counteracting oxidative stress and buffering mitophagy. Through this regulation, PGC-1α functions as a positive regulator of mitochondrial biogenesis moving the skeletal muscle balance towards the production of new mitochondria. Conversely, the downregulation of PGC-1α leads to alteration of mitochondrial network promoting the induction of mitophagy through a ROS-dependent binding of FOXO1 transcription factor on LC3 and PINK1 gene promoter