Table 1 Differential expression of ATF4 and its selected transcriptional targets in HCT116 cells after mitochondrial ETC complex III inhibition with myxothiazol for 5 h (M5), 13 h (M13), 17 h (M17) and 13 h in the presence of uridine (MU13)

From: A sustained deficiency of mitochondrial respiratory complex III induces an apoptotic cell death through the p53-mediated inhibition of pro-survival activities of the activating transcription factor 4

Gene ID

Gene name

mRNA fold changes a

  

M5

M13

M17

MU13

Atf4

activating transcription factor 4 (tax- responsive enhancer element B67)

2.46

0.43

0.24

1.76

Trib3

tribbles homolog 3 (Drosophila)

5.41

NC

0.55

3.24

Ddit3

DNA-damage-inducible transcript 3, C/EBP homologous protein (CHOP)

5.53

2.07

NC

2.77

Chac1

ChaC, cation transport regulator homolog 1 (E. coli)

7,9

NC

0,28

4.98

Slc7a11

solute carrier family 7, (cationic amino acid transporter, y+ system) member 11

2.41

NC

0.24

4.76

Asns

asparagine synthetase

3.56

2.98

1.53

3.05

  1. Abbreviation: NC, no change.
  2. aFold change in mRNA levels according to mRNA-seq data is presented (FDR<0.05).
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