Table 2 Differential expression of known transcriptional targets of ATF4 (except those listed in the Table 1) from the lists of genes upregulated by mitochondrial ETC complex III inhibition in the absence of p53 activation (presented in Tables S1 and S2). HCT116 cells were treated with myxothiazol for 5 h (M5), 13 h (M13), 17 h (M17) and for 13 h in the presence of uridine (MU13)

#	Gene symbol	Ensemble ID	^a mRNA fold changes				Ref
			M5	M13	M17	MU13
Amino acid transporters
1	Slc7a11	ENSG00000151012	2.41	NC	0.24	4.76
2	SLC7A1	ENSG00000139514	1.78	0.67	NC	1.94
3	SLC6A9	ENSG00000196517	2.97	NC	NC	3.12	¹⁰
4	Slc38a2	ENSG00000134294	1.90	0.49	0.46	1.425
5	SLC1A5	ENSG00000105281	1.69	1.27	NC	1.88
6	SLC7A5	ENSG00000103257	1.81	1.89	NC	2.72
Aminoacyl-tRNA synthetases
7	AARS	ENSG00000090861	1.86	NC	0.60	1.98
8	mars	ENSG00000166986	1.53	NC	NC	1.87
9	SARS	ENSG00000031698	1.78	NC	0.77	2.10	¹⁰
10	Gars	ENSG00000106105	2.03	NC	0.71	1.62
11	Yars	ENSG00000134684	1.62	NC	NC	1.71
12	eprs	ENSG00000136628	1.43	NC	NC	1.29
Other ATF4 targets
13	FGF19	ENSG00000162344	1.97	NC	NC	1.97	²⁷
14	ddit4	ENSG00000168209	4.36	NC	NC	1.95
15	JDP2	ENSG00000140044	2.67	NC	NC	2.44
16	CTH	ENSG00000116761	1.38	NC	NC	1.45
17	Eif1	ENSG00000173812	2.06	0.66	NC	1.41	¹⁰
18	EIF4EBP1	ENSG00000187840	1.35	0.78	NC	1.41
19	STC2	ENSG00000113739	2.63	NC	0.74	2.1
20	GCLC	ENSG00000001084	1.72	NC	NC	1.51	²⁸
21	Psat1	ENSG00000135069	2.5	NC	0.66	2.37
22	ANK2	ENSG00000145362	1.93	NC	NC	2.06
23	Klf4	ENSG00000136826	2.05	NC	0.66	1.45
24	RHBDD1	ENSG00000144468	1.36	0.56	NC	1,41
25	Xpot	ENSG00000184575	1.52	NC	0.64	1.55	¹⁰
26	FAM129A	ENSG00000135842	2.59	1.95	1.4	3.37
27	GPT2	ENSG00000166123	1.59	1.34	NC	1.94
28	Arhgef2	ENSG00000116584	1.83	1.58	NC	2.10
29	Mid1ip1	ENSG00000165175	1.33	1.25	NC	1.72
30	Gtpbp2	ENSG00000172432	2.15	1.30	NC	2.05

Abbreviation: NC, no change.
^aFold change in mRNA levels according to mRNA-seq data is presented (FDR<0.05).

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