Figure 5
From: Neuritin can normalize neural deficits of Alzheimer’s disease
Soluble neuritin rescues LTP in the hippocampi of Tg2576 mice. (a) LTP in the Schaffer collateral pathway of 6-month-old WT littermates and Tg2576 mice. Field EPSPs were recorded from the CA1 region of acute hippocampal slices and LTP was induced by TBS, denoted as a black arrow. LTP is expressed as mean±S.E.M.% of baseline slopes of fEPSPs recorded over at least a 20-min baseline period. Insets show representative traces at the color-matched time points (Calibration: 1 mV and 10 ms). (b) LTP of Tg2576 mice that underwent the osmotic infusion of either aCSF or recombinant neuritin peptide. Arrow, insets, and calibration as in a. (c) A summary histogram for the synaptic potentiation at 1 h after LTP induction in a and b. The magnitude of LTP in Tg2576 mice significantly decreased (WT, 166.8±10.9%, n=8 slices from 3 mice versus Tg2576, 101.4 ±4.8%, n=9 slices from 3 mice), but resumed by osmotic infusion of soluble neuritin peptide (Tg2576-Control, 100.5±4.9%, n=12 slices from 4 mice versus Tg2576-Neuritin, 146.3±22.2, n=9 slices from 4 mice). Statistical significance is expressed as *P<0.05 and ***P<0.001
