Figure 5

Role of caspases and their inhibitors in sepsis: schematic representation indicating the involvement of caspases in sepsis is shown. The pan caspase inhibitors, zVAD.fmk, and VX-166, and the caspase-3-specific inhibitor, M-791, show potential beneficial outcome in sepsis. Necrostatin-1 (Nec-1) serves as the inhibitor of RIPK1