Table 2 List of selected genes altered in the gene array

From: Analysis of gene expression array in TSC2-deficient AML cells reveals IRF7 as a pivotal factor in the Rheb/mTOR pathway

Gene symbol

Gene title

Fold change

  

621.102 FTS versus 621.102 control

621.102 Rapa versus 621.102 control

621.103 Con versus 621.102 control

ADM

Adrenomedullin

−1.5

−1.9

−4.3

APOBEC3G

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G

−3.4

−2.9

−19.7

BST2

Bone marrow stromal cell antigen 2

−2.5

−9.9

−23.0

C3AR1

Complement component 3a receptor 1

−2.0

−6.2

−8.6

CASP1

Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)

−1.9

−3.8

−3.3

CCL2 a

Chemokine (C−C motif) ligand 2

−2.0

−1.6

−31.6

COL14A1

Collagen, type XIV, alpha 1

−2.5

−2.1

−19.3

COL3A1 a

Collagen, type III, alpha 1

−1.6

−1.6

−54.9

CPM

Carboxypeptidase M

−3.5

−1.6

−2.4

DDX58

DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

−1.5

−2.3

−13.2

DRAM1

DNA, damage-regulated autophagy modulator 1

−2.0

−1.9

−6.8

GBP1

Guanylate binding protein 1, interferon-inducible, 67 kDa

−2.7

−2.1

−8.2

GBP2 a

Guanylate binding protein 2, interferon-inducible

−1.6

−4.2

−16.2

HLA-F

Major histocompatibility complex class I, F

−2.5

−2.1

−6.4

HSPA5

Heat shock 70-kDa protein 5 (glucose-regulated protein, 78 kDa)

−1.5

−6.5

−6.1

ICAM1

Intercellular adhesion molecule 1

−1.5

−1.6

−3.7

IDO1

Indoleamine 2,3-dioxygenase 1

−3.7

−8.0

−8.0

IFI27

Interferon, alpha-inducible protein 27

−1.7

−5.2

−7.4

IFIH1

Interferon induced with helicase C domain 1

−1.8

−2.1

−33.4

IFIT2 a

Interferon-induced protein with tetratricopeptide repeats 2

−1.7

−8.2

−16.0

IFITM1 a

Interferon-induced transmembrane protein 1 (9–27)

−1.7

−2.6

−128.5

MMP3

Matrix metallopeptidase 3 (stromelysin 1, progelatinase)

−1.7

−2.2

−8.1

PLSCR1

Phospholipid scramblase 1

−2.0

−2.6

−13.2

RSAD2

Radical S-adenosyl methionine domain-containing 2

−2.3

−8.8

−71.4

STAT1 a

Signal transducer and activator of transcription 1, 91 kDa

−1.8

−4.5

−25.5

TNFSF10

Tumor necrosis factor (ligand) superfamily, member 10

−1.8

−5.5

−12.8

TRIM22

Tripartite motif-containing 22

−1.8

−1.9

−10.0

TRIM5

Tripartite motif-containing 5

−3.0

−2.1

−3.3

TSC2 a

Tuberous sclerosis 2

1.5

1.6

2.9

HES6 a

Hairy and enhancer of split 6 (Drosophila)

1.6

1.7

6.4

RPL7

Ribosomal protein L7

1.6

2.6

4.5

  1. aGenes that were validated using qRT-PCR