Figure 5 | Cell Death & Disease

Figure 5

From: The malignant phenotype in breast cancer is driven by eIF4A1-mediated changes in the translational landscape

Figure 5

eIF4A1-dependent and -independent mRNAs have qualitatively different 5′UTRs. eIF4A1-dependent and -independent mRNA 5′UTRs were characterized in terms of (a) G/C content, (b) predicted folding stability and (c) 5′UTR length. P-values were calculated using Kolmogorov-Smirnov test. (d) Recurrent sequence motifs were discovered in the eIF4A-dependent 5′UTRs. (e) GGC-containing motifs were enriched in eIF4A-dependent sequences, as was the predicted potential to form classical G-quadruplexes

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