Figure 1 | Cell Death & Disease

Figure 1

From: Primary clear cell renal carcinoma cells display minimal mitochondrial respiratory capacity resulting in pronounced sensitivity to glycolytic inhibition by 3-Bromopyruvate

Figure 1

ccRCC cells have low mitochondrial content and are highly glycolytic. Heatmaps illustrating relative mRNA transcript levels of genes involved in the glycolytic pathway (a) or mitochondrial metabolism (b) in 505 ccRCC tumor and 70 normal kidney samples as obtained from the TCGA database. Boxplots summarize the gene expression data presented in the heatmaps. For each sample the mean expression values of the glycolytic and mitochondrial genes, respectively, was calculated. These mean values were then plotted stratified on ccRCCs and normal kidney samples. (c) Immunohistochemical staining of ccRCC or normal kidney tissue samples for Glut1 (upper panel) or MTCO2 (lower panel). (d) Box plot showing the relative expression levels of glycolytic genes in various cancer types included in the TCGA data collection. BLCA, Bladder Urothelial Carcinoma; BRCA, Breast invasive carcinoma; COAD, Colon adenocarcinoma; GBM, Glioblastoma multiforme; HNSC, Head and Neck squamous cell carcinoma; KICH, Kidney Chromophobe; KIRC, Kidney renal clear cell carcinoma; LAML, Acute Myeloid Leukemia; LGG, Brain Lower Grade Glioma; LUAD, Lung adenocarcinoma; LUSC, Lung squamous cell carcinoma; OV, Serous Cystadenocarcinoma; PRAD, Prostate adenocarcinoma; READ, Rectum adenocarcinoma; SKCM, Stomach adenocarcinoma; THCA, Thyroid Carcinoma; UCEC, Uterine Corpus Endometrial Carcinoma

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