Figure 6 | Cell Death & Disease

Figure 6

From: Primary clear cell renal carcinoma cells display minimal mitochondrial respiratory capacity resulting in pronounced sensitivity to glycolytic inhibition by 3-Bromopyruvate

Figure 6

SLC16A1 expression is elevated in ccRCC cells. (a) RNA levels of the monocarboxylate transporter SLC16A1 are elevated in ccRCC tissue compared with normal kidney. Data obtained from TCGA data collection and two separate publically available gene arrays (see Materials and Methods). (b) Immunohistochemical staining of MCT1 in cultured primary ccRCC, normal kidney epithelial cells and the continuous cell line SKRC17. The images shown are representative of four separate cultures of each cell type that were stained for MCT1. (c) Relative SLC16A1 mRNA levels in eight normal kidney cultures (R104N, R117N, R124N, R127N, R130N, R131N, R132N and R134N), six ccRCC samples (R103T, 3122T, R125T, R130T, R132T and R173T) and the seven established cell lines, determined by quantitative real-time PCR

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