Figure 6
From: TSC2/mTORC1 signaling controls Paneth and goblet cell differentiation in the intestinal epithelium
TSC2/mTOR signaling pathway regulates intestinal cell differentiation through Notch1. (a) WT and TG mice were treated with or without rapamycin for 6 days. The decreased immunohistochemical staining for NICD and Hes1 (arrow) demonstrated the inhibition of Notch signaling by rapamycin in the intestinal epithelium. (b) Mucosal protein lysates extracted from WT and TG mice treated with or without rapamycin for 6 days were used for western blot detection of NICD and Hes1 protein expression. Scale bars, 50 μm
