Figure 6 | Cell Death & Disease

Figure 6

From: Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling

Figure 6

Metformin inhibits ESCC tumor growth in vivo. (a) Tumor growth curve of metformin-treated mice (250 mg/kg body weight) and control (vehicle treated) mice. Data represent the mean±S.D. of eight mice in each group. *P<0.05 by the Student’s t-test. (b) Dissected tumor was photographed and weight was measured. *P<0.05 by Student’s t-test. (c) Representative images ( × 400) of IHC analysis of p-Stat3, cyclin D1, Bcl-2, PCNA, TUNEL and p62 in tumors. (d) Western blots of LC3 in tumor tissues. β-Actin was probed as the loading control

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