Figure 1 | Cell Death & Disease

Figure 1

From: Overcoming inherent resistance to histone deacetylase inhibitors in multiple myeloma cells by targeting pathways integral to the actin cytoskeleton

Figure 1

Determination of sensitivity of HMCL to HDACi LBH589, SAHA and FK228. (a) Nine HMCL were exposed to three doses of HDACi (LBH589 and FK228 at 10, 50 and 100 nM and SAHA at 1, 5 and 10 μM) for 48 h and the proportion of cell death determined through flow cytometric enumeration of propidium iodide staining. Cell death is normalized to proportion of cell death in untreated samples. Data are represented as mean±S.E.M. from three experiments. (b) Representation of cell death induced by LBH589 (100 nM), SAHA (10 μM) and FK228 (100 nM) in nine HMCL. Mean cell death induced by each HDACi is represented. Different shades represent the amount of cell death as shown in the boxes.

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