Figure 6 | Cell Death & Disease

Figure 6

From: Overcoming inherent resistance to histone deacetylase inhibitors in multiple myeloma cells by targeting pathways integral to the actin cytoskeleton

Figure 6

Targeting the actin cytoskeleton overcomes resistance to HDACi in primary MM. (a) Graphs representing the proportion of cell death induced in MM patients (n=6) treated with HDACi – LBH589 (5 nM), GSK1120212 (0.5 μM) and combination. (b) Graphs representing the proportion of cell death induced in MM patients (n=6) treated LBH589 (5 nM), TAE226 (0.5 μM) and combination. (c) Graphs representing the proportion of cell death induced in MM patients (n=6) treated with LBH589 (5 nM), BKM120 (0.5 μM) and combination for 72 h. Cell death was estimated through flow cytometric enumeration of APO2.7 staining in CD38+ and CD45− MM cells. Numbers on top of the bars representing cell death proportion in the drug combination samples represent the SQ of the stated combinations. SQ of >1 represents a synergistic combination

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