Figure 6 | Cell Death & Disease

Figure 6

From: APP intracellular domain acts as a transcriptional regulator of miR-663 suppressing neuronal differentiation

Figure 6

Proposed model of the APP-AICD-miR-663 signaling in hNSC differentiation. APP is located at the plasma membrane of hNSCs. Ligand binding to APP triggers an intramembrane cleavage of APP to generate the AICD, which translocates to the nucleus. Nuclear AICD promotes the expression of miRNAs, such as miR-663, which suppress the expression of genes such as FBXL18 and CDK6, to inhibit hNSC neuronal differentiation

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