Figure 3 | Cell Death & Disease

Figure 3

From: FAS-ligand regulates differential activation-induced cell death of human T-helper 1 and 17 cells in healthy donors and multiple sclerosis patients

Figure 3

Sensitivity of Th1 cells to TCR-mediated apoptosis involves caspases and FASL expression. Pools of Th0, Th1, Th17 and Th1/17 clones from the same donor were stimulated as indicated. At 24 h (a, c and d) or 6 h (b) after stimulation, expression of caspases (a and d) or FASL (b) was analysed by western blot and densitometry; apoptosis was analysed by flow cytometry (c). Results are expressed as mean values (±S.D.) of eight (a), four (b) and six (c) of independent experiments performed on eight (a), four (b) and six (c) HD; representative experiment is reported (d). A paired t-test was used to compare sample conditions. *P<0.05, **P<0.005, ***P<0.001

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