Figure 5 | Cell Death & Disease

Figure 5

From: FAS-ligand regulates differential activation-induced cell death of human T-helper 1 and 17 cells in healthy donors and multiple sclerosis patients

Figure 5

FASL transcription is reduced in Th17 compared with Th1 cells. Expression of FASL, EGR1, EGR2, EGR3, IRF1, IRF2 and MYC in pools of Th1 and Th17 clones was analysed by real-time PCR. Threshold cycle values were normalised to mRNA of ribosomal protein L-34 gene. Data are mean±S.D. of independent experiments performed on independent donors (a–c). Graphs of EGR1, EGR2, EGR3, IRF1, IRF2 and MYC transcript levels, obtained from six independent experiments (pools of Th1 and Th17 clones unstimulated and stimulated with anti-CD3-28), were correlated to FASL transcript levels, using Pearson's correlation. R indicates correlation coefficient (d)

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