Figure 2
From: Loss of Caspase-3 sensitizes colon cancer cells to genotoxic stress via RIP1-dependent necrosis
Caspase-3 KO tumors show increased response to 5-FU in vivo. (a) The relative growth of WT and C3KO tumors in PBS and 5-FU groups. 5-FU (50 mg/kg) was given intraperitoneally (IP) every other day for 14 days when tumors reached ~50 mm3 (day 0). N=9/group. (b) H&E staining of tumors with indicated genotypes after the last treatment. (c) Staining of active caspase-3 and TUNEL in the tumors after the last treatment. Scale bars, 200 μm. (d) Quantification TUNEL-positive cells in HCT116 WT and C3KO tumors in (c). Data are the mean + S.E.M. of three randomly chosen tumors in each group. **P<0.01
