Figure 5
From: Geniposide promotes beta-cell regeneration and survival through regulating β-catenin/TCF7L2 pathway
Geniposide promoted β-cell regeneration in vivo. (a) Proliferation of β-cell was measured in mice pancreatic sections by triple staining for Ki67 in red (indicated by white arrows), insulin in green, and DAPI in blue. (b) The PDX-1 and Ngn3 expressions in CK19-positive ductal epithelial cells. Representative images of ductal epithelial cells after triple staining for PDX-1 or Ngn3 in red, CK19 in green, and DAPI in blue were shown. (c) Small ICCs originated in the vicinity of the ducts. Representative pictures of ICCs were shown as insulin-positive staining (indicated by white arrows). Values are representative of four slides spanning the whole pancreas of each mouse and six mice per group. Data are shown as mean±S.E. ( #P<0.01 vehicle to WT or ND group; *P<0.01 geniposide to vehicle group). Scale bars, 20 μm
