Figure 1 | Cell Death & Disease

Figure 1

From: Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation

Figure 1

Amino-acid substitutions in the Qp site of CII. (a) Multiple species alignment of the SDHC region bordering the Qp site shows a high level of conservation. Amino-acid substitutions prepared for this study are indicated in human SDHC. (b) Three dimensional representation of CII and the topology of the Qp site. SDHC residues mutated in this study are indicated by arrows. Displayed is the humanized crystal structure of porcine CII.3 (c) A snapshot from molecular dynamics simulation of MitoVES interaction with the Qp site of CII in the presence of phospholipid bilayer.16 One of the possible conformations of MitoVES is shown in orange, substituted SDHC residues are depicted in magenta

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