Figure 8
From: Che-1 modulates the decision between cell cycle arrest and apoptosis by its binding to p53
Model to explain the effects of Che-1/p53 binding. In the first hours of DNA damage, phosphorylated Che-1 sits in a ternary complex with p53 and Brca1, directing p53 transcription towards growth arrest genes. When cells undergo apoptosis, Pin1 produces p53 modifications resulting in the disassembly of the complex and p53 is free to be recruited to the pro-apoptotic genes
