Figure 1
From: Stressing out the ER in aminoglycoside-induced hearing loss
Models of aminoglycoside-induced ototoxicity. (a) Aminoglycosides activate the UPR system in cell culture. (b) Cochlear explant treated with geneticin undergoes ER stress. (c) XBP1 haploinsufficiency (XBP1+/−) specifically affects SGCs density and synaptic connections (synaptic ribbons)
