Figure 1 | Cell Death & Disease

Figure 1

From: Neural stem cell transplantation at critical period improves learning and memory through restoring synaptic impairment in Alzheimer’s disease mouse model

Figure 1

NSC transplanted at the advanced stage of AD in Tg2576 mice did not show the improvement in behavior and pathology. (a) We transplanted the NSC into 15-month-old Tg2576 mice, and then performed learning and memory tests 2 month after NSC treatment. After then, mice brains were isolated and the brain slices were stained with Congo red for the detection of amyloid plaques. (b) Mean latency in reaching the hidden platform on the spatial learning task. (c) The probe test represents that Tg-sham group mice cannot remember the zone 4 where the platform located during the training period. Tg-NSC group mice were not improved in the memory. (d) Histological analysis was carried out at the age of 17.5-month (2.5 months after the transplantation). In cortex and hippocampus, amyloid plaques were detected by immunohistochemistry using 6E10 antibody and Congo red staining. (e) The number of amyloid plaques was counted in brain slices containing hippocampal region of each group and calculated the average number of plaques per brain slices. There were no significant differences of amyloid plaque numbers at the cortex and hippocampal area in Tg-NSC group compared with the Tg-sham group. *P<0.05, **P<0.01, ***P<0.001 by one-way ANOVA. CX, cortex; EC, entorhinal cortex; FC, frontal cortex; PFC, piriform cortex

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