Figure 5 | Cell Death & Disease

Figure 5

From: Neural stem cell transplantation at critical period improves learning and memory through restoring synaptic impairment in Alzheimer’s disease mouse model

Figure 5

Endogenous neurogenesis was increased in the NSC-transplanted Tg2576 mice. (a) At 2.5 months after transplantation, endogenous neurogenesis was observed in the DG of hippocampus by immunohistochemisty using anti-DCX antibody. DCX-positive cells were calculated in mm2 area of DG. Graph represents that endogenous neurogenesis was enhanced by NSC transplantation. (b) The levels of PSA-NCAM were analyzed by immunohistochemistry. In Tg-NSC group, the levels of PSA-NCAM were increased compared with the Tg-sham group. Graph represents that PSA-NCAM was enhanced by NSC transplantation. (c) In Tg-NSC group, the levels of PSA-NCAM and VEGF were increased compared with the Tg-sham group. Quantitative analysis shows that NSC transplantation significantly increased the level of PSA-NCAM and VEGF expressions. *P<0.05, by one-way ANOVA

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