Figure 6 | Cell Death & Disease

Figure 6

From: Neural stem cell transplantation at critical period improves learning and memory through restoring synaptic impairment in Alzheimer’s disease mouse model

Figure 6

Synaptic density was increased in the NSC-transplanted Tg2576 mice. (a and b) PSD-95 expression level was analyzed by western blot. The level of PSD-95 was increased in the cerebral cortical area of Tg-NSC mice brains at 2.5 months after the transplantation compared with the Tg-sham group (a). In hippocampal synaptosomal fractions, PSD-95 level of Tg-NSC mice brains was increased compared with the Tg-sham mice brains (b). Quantitative data for PSD-95 are expressed as mean ±S.E.M. *P<0.05, by one-way ANOVA. (c) At 2.5 months after NSC transplantation, progressive reduction in MAP2 immunoreactivity was observed in the cortex and CA1 area of Tg-sham group mice. However, dendritic spine morphology was repaired and the density was increased by NSC treatment

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