Figure 3 | Cell Death & Disease

Figure 3

From: Dual induction of apoptotic and autophagic cell death by targeting survivin in head neck squamous cell carcinoma

Figure 3

YM155 decreases phosphorylation of mTOR in HNSCC cell line. (a) CAL27 cells were treated with indicated doses YM155 for 24 h. Western blot analysis showed the weakened phosphorylation of p-Akt, p-mTOR, p-S6 accompanied with decreased cell cycle markers including p-Rb, cyclin D1 and prosurvival markers Bcl2 and Bcl2l1. (b) Immunofluorescence showed the decreased cytoplasm and membrane expression of p-S6 in YM155 group

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