Figure 4 | Cell Death & Disease

Figure 4

From: Dual induction of apoptotic and autophagic cell death by targeting survivin in head neck squamous cell carcinoma

Figure 4

Targeting survivin by YM155 delays onset of HNSCC in Tgfbr1/Pten 2cKO mice. (a) Tgfbr1/Pten 2cKO mice bearing carcinoma were treated with 5 mg/kg YM155 intraperitoneally (i.p) daily for 14 days or vehicle control treated. (b) Representative photos of mice tumor with external head and neck (left) and tongue (right) after treatment with YM155 or vehicle in day 35 and day 42 after tumor. (c) Tumor growth measured every other day. Mean±S.E.M. of tumor sizes were shown; *P< 0.05. (d) Tongue tumor number were assessed in YM155 and control group. (e) Drug toxicity were assessed by gained body weight of Tgfbr1/Pten 2cKO mice in each group; Mean±S.E.M., **P<0.01. (f) Kaplan–Meier curve of survival of Tgfbr1/Pten 2cKO mice; Mean±S.E.M.; *P<0.05

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