Table 2 The top 10 downregulated and upregulated genes with a P-value <0.05 and ascribed to ‘apoptosis’ are shown

From: The calcineurin/NFAT pathway is activated in diagnostic breast cancer cases and is essential to survival and metastasis of mammary cancer cells

Gene’s name

Log ratio

Relation to breast cancer

WISP1*

−2.912

Induction of WISP1 correlates with invasive breast cancer oncogenesis and reduced type 1 cell-mediated cytotoxic immunity: a retrospective study (Klinke et al.,32)

SERPINE1*

−2.295

Plasma PAI-1 levels in breast cancer-relationship with clinical outcome (Ferroni et al.,33)

FST*

−2.073

FST found upregulated in highly invasive MDS-MB-435 overexpressing alpha4beta6 integrins (Chen34)

ADAMTS1*

−2.067

The ADAMTS1 protease gene is required for mammary tumor growth and metastasis (Ricciardelli et al.,14)

NRP1*

−2.033

Neuropilin-1 is expressed by breast cancer stem-like cells and is linked to NFkB activation and tumor sphere formation (Glinka et al.,35)

NTS*

−2.024

The neurotensin receptor-1 pathway contributes to human ductal breast cancer progression (Dupouy et al.,36)

ROR1*

−1.970

ROR1 is expressed in human breast cancer and associated with enhanced tumor cell growth (Zhang et al.,37)

ADAM12*

−1.940

ADAM12 redistributes and activates MMP-14, resulting in gelatin degradation, reduced apoptosis and increased tumor growth (Albrechtsen et al.,38)

DAG1

−1.696

 

ABCG2*

−1.510

Breast cancer resistance protein

IRF8*

1.616

Epigenetic inactivation of IRF8 in breast carcinoma (among other carcinoma lines; Lee et al.,39)

IFI16*

1.663

Differential regulation of estrogen receptor a expression in breast cancer cells by metastasis-associated protein 1 (Kang et al.,40)

HIST1H1C

1.799

 

ITGA1

1.875

 

NPTX1

1.890

 

CXCR3*

2.004

C-X-C ligand 10 and C-X-C receptor 3 status can predict tamoxifen treatment response in breast cancer patients (Hilborn et al.,41)

KLF2*

2.217

Silencing of KLF2 by the histone methyltransferase EZH2 in human cancer (Taniguchi et al.,42)

EYA2

2.316

 

TRIB2

2.414

 

TXNIP*

2.680

Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer (Cadenas et al.,43)

  1. The asterisk indicates that the gene has been associated with breast cancer in the literature. Column 2 indicates the log ratio (ln2) measured in the Affymetrix screen. Column 3 lists one reference of the link between the indicated gene and breast cancer. NA, not applicable.
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