Figure 6
From: Targeting Mdmx to treat breast cancers with wild-type p53
KD of Mdmx induced growth inhibition also in wt p53 luminal BrCa cell line MPE600. MPE600 cells transduced with either shMdmx constructs or shRNA controls were either not treated or treated with DOX (2.5 ng/ml) for 8 days and analyzed by western blotting (a) with protein staining for Mdmx, p53, p21, Mdm2 and USP7. Cell growth inhibition under the same conditions was demonstrated by a colony assay, representative plates are shown in b and the results are summarized in c
