Figure 7
From: Targeting Mdmx to treat breast cancers with wild-type p53
KD of Mdmx growth inhibited wt p53 basal-like SKBR7. Wt p53 basal-like SKBR7 cells transduced with either shMdmx constructs or shRNA controls were either not treated or treated with DOX (2.5 and 5 ng/ml) for 8 days and analyzed by western blotting (a) with protein detection of Mdmx, p53 and USP7. A colony assay of 2.5 ng/ml DOX-treated samples and controls demonstrated significant growth inhibition with Mdmx KD as visualized in b and as quantified in c
