Table 2 Representative key epigenetic modifications found in multiple sclerosis patients
From: Multiple sclerosis: getting personal with induced pluripotent stem cells
Gene | Epigenetic abnormality | Source | Reference |
|---|---|---|---|
TMEM | DNA methylation | CD4+ cells | Baranzini et al.52 |
PEX14 | DNA methylation | CD4+ cells | Baranzini et al.52 |
CDKN2B | DNA methylation | Cell-free plasma DNA | Liggett et al.53 |
FAS | DNA methylation | Cell-free plasma DNA | Liggett et al.53 |
MCJ | DNA methylation | Cell-free plasma DNA | Liggett et al.53 |
MDGI | DNA methylation | Cell-free plasma DNA | Liggett et al.53 |
PGK1 | DNA methylation | Cell-free plasma DNA | Liggett et al.53 |
TP73 | DNA methylation | Cell-free plasma DNA | Liggett et al.53 |
CDH1 | DNA methylation | Cell-free plasma DNA | Liggett et al.53 |
PAX5 | DNA methylation | Cell-free plasma DNA | Liggett et al.53 |
SYK | DNA methylation | Cell-free plasma DNA | Liggett et al.53 |
Not specified | H3 citrullination | White matter | Mastronardi et al.54 |
TNFalpha | H3 citrullination | PBMCs | Sharma et al.55 |
miR-17 | Downregulation | Whole blood | Cox et al.57 |
miR-20a | Downregulation | Whole blood | Cox et al.57 |
miR-17-5p | Upregulation | CD4+ cells | Jr Ode et al.56 |
miR-155 | Upregulation | CD4+ cells | Jr Ode et al.56 |
miR-25 | Downregulation | T-regulatory cells | Jr Ode et al.56 |
miR-106b | Downregulation | T-regulatory cells | Jr Ode et al.56 |
