Figure 5 | Cell Death & Disease

Figure 5

From: Estrogen receptor α regulates non-canonical autophagy that provides stress resistance to neuroblastoma and breast cancer cells and involves BAG3 function

Figure 5

Inhibiting the late phase of autophagy via BafA1 results in enhanced cell death in ERα-expressing cells upon exposure to oxidative stress induced by H2O2. SK-01, SK-ERα, SK-ERβ and MCF-7 cells were treated with vehicle control or 400 μM and 600 μM H2O2 with or without BafA1 (500 nM) for 24 h and cell death was quantified by flow cytometry after propidium iodid staining. Values of three independent experiments in each panel are expressed as mean±S.E.M. and representative data from the experiments are shown in FACS dot plot profiles. (*) on bars represents statistical significance of P<0.05 comparing two groups and n.s. displays no statistical significant difference

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