Figure 2 | Cell Death & Disease

Figure 2

From: Protein kinase R-like ER kinase and its role in endoplasmic reticulum stress-decided cell fate

Figure 2

Schematic diagram of signal-transduction network during ER stress-induced cell apoptosis. Apoptotic signals are transduced through ATF6-, IRE1- and PERK-governed signaling pathways in ER stress-induced apoptosis. This diagram mainly showed PERK-associated pathways, whereas ATF6- and IRE1-regulated pathways are briefly demonstrated. According to previous studies, in ER stress-induced apoptosis, PERK/eIF2α/ATF4, PERK/CaN, PERK/eIF2α/TDAG51, PERK/eIF2α/IAP2 and PERK/NRF2 pathways are considered PERK-associated

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