Table 1 Several molecules related with PERK-induced cell apoptosis
From: Protein kinase R-like ER kinase and its role in endoplasmic reticulum stress-decided cell fate
Molecules | Upstream molecules | Effect of upstream molecules | Direct/indirect interact with PERK | Downstream molecules | Effect to downstream molecules | Consequence of activation |
|---|---|---|---|---|---|---|
eIF2α | PERK | Activation | Direct | ATF4 | Activation | Proapoptosis |
ATF4 | PERK, eIF2α | Activation | Indirect | CHOP, Noxa | Activation | Proapoptosis |
cIAPs | PERK, eIF2α, NAT1, DAP5 | Activation | Unknown | Caspase-3, caspase-7, caspase-9 | Inhibition | Antiapoptosis |
TDAG51 | PERK, eIF2α | Activation | Unknown | CD95/Fas | Activation | Proapoptosis |
NRF | PERK | Activation | Direct | Bcl2 | Activation | Antiapoptosis |
TRIB3 | PERK, ATF4, CHOP | Activation | Indirect | NF-κB, Notch1 | Activation | Proapoptosis |
CaN | PERK | Activation | Direct | RyR2 | Activation | Proapoptosis |
