Figure 2 | Cell Death & Disease

Figure 2

From: Chop deficiency prevents UUO-induced renal fibrosis by attenuating fibrotic signals originated from Hmgb1/TLR4/NFκB/IL-1β signaling

Figure 2

Analysis of Chop expression and ER stress markers in the kidneys with UUO-induced fibrosis. WT mice were first subjected to UUO procedures and then killed after day 14 of UUO induction. Sham-operated mice were served as controls. (a) H&E (left panel) and PAS (right panel) staining showing pathological changes following UUO induction. (b) Masson's trichrome staining showing collagen deposition in UUO-induced kidneys. (c–g) Western blot analysis of Chop (c) and ER stress markers Bip (d), Perk (e), Ire-1α (f) and Atf-6 (g). **P<0.01 and ***P<0.001

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