Figure 4
From: DED or alive: assembly and regulation of the death effector domain complexes
Binding modes of FLIP–FADD and procaspase 8–FADD interactions. FLIP binds to the DED of FADD using its DED2, whereas procaspase-8 binds to FADD using its DED1. The main residues that are important for the interactions are shown in grey: FLIP uses its F114 residue on the α2 helix to bind into a groove between α1/α4 helices in the DED of FADD with a reciprocal interaction from FADD H9 into the α2/α5 hydrophobic patch of FLIP; procaspase-8 uses the Y8 residue on its α1 helix to bind into the hydrophobic patch between the α2/α5 helices in FADD, with a reciprocal interaction from FADD F25 into the α1/α4 groove in procaspase-8
