Figure 5 | Cell Death & Disease

Figure 5

From: Silencing NFBD1/MDC1 enhances the radiosensitivity of human nasopharyngeal cancer CNE1 cells and results in tumor growth inhibition

Figure 5

NFBD1 regulates DNA-PKcs and Rad51 foci formation. (a and b) Inhibition of NFBD1 resulted in defective DNA-PKcs and Rad51 foci formation after IR exposure. Cells were untreated or irradiated with 8 Gy IR, fixed at 1 h post irradiation and stained with the indicated antibodies (mouse anti-NFBD1, rabbit anti-DNA-PKcs (pT2609) and rabbit anti-Rad51). (c) CNE1 cells were untreated or irradiated with 8 Gy IR, harvested 1 h later and subjected to western blotting analysis with indicated antibodies. Representative blots were shown with β-actin as loading control

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